Unlike the numerous clans of the previous game, Vampire: The Requiem only has 5 main clans (although two others are presented in other books). However, there are numerous bloodlines, so it’s very easy to make you nosferatu different from the next.
My major complaint about this game is that I haven’t really got to play it much. I have several books and I love what I’ve read, but I’ve yet to get a good group together to run and/or play it.
Below is the “intro” video that White Wolf released when the game was released. It gives a good summary I think.